Speciality
Spotlight

 




 


Oncology


 

 





Melanoma

   

  • J
    Lee, Sanjay Logani, et al (N. W. Univ Med School,
    Chicago)

    Preretinal Neovascularisation Associated with
    Choroidal Melanoma


    BJO, Nov.2001, 85(11): 1309-1312

      

    The authors report 3 cases of choroidal melanoma with
    the very rare finding of overlying pre-retinal
    neovascularisation (NVE).

      

    All 3 patients had choroidal melanomas, localized serous
    retinal detachment and NVE.

      

    Two cases showed definite retinal capillary
    non-perfusion. One of these two patients showed retinal
    telangiectasis.

      

    One patient’s melanoma responded quickly to iodine-125
    plaque radiotherapy but retinal neovascularization
    persisted and caused vitreous hemorrhage.

      

    Scatter photocoagulation was successful in causing the
    complete regression of neovascularization.

      

    The other 2 patients had their eyes enucleated, and in
    one of the cases preretinal vessels were seen in
    histological sections.

      

    Possible aetiologies of pre-retinal neovascularization
    include (i) release of tumor angiogenic factors (ii)
    inflammation (iii) chronic retinal detachment with
    secondary retinal ischemia (iv) retinal vascular
    occlusion secondary to retinal vessel invasion by the
    tumor or (v) following radiation therapy.

       

  • L
    Lumbroso, L Desjardins, et al (Opth.Dept. Institute
    Curie, Paris, France)    

    Intraocular inflammation after proton beam
    irradiation for uveal melanoma
        

    BJO, 2001; 85:1305-1308   

                                                        

    Data from a cohort of patients with uveal melanoma who
    were treated by proton beam irradiation between 1991 and
    1994 were analyzed.     

                         

    28% of patients treated during the above period
    presented with ocular inflammation.    

                                                 

    Risk factors were correlated with larger lesions.
    Multivariate analysis identified initial tumour height
    and irradiation of a large ocular volume as 2 important
    risk factors.           

                                              

    Ocular inflammation usually consisted of mild anterior
    uveitis, which resolved rapidly after use of local
    steroids and cycloplegics. 

                                           

    Inflammation may also be associated with tumour necrosis
    (spontaneous or after irradiation). Transient
    inflammation during follow-up of these patients maybe
    related to release of cytokines during tumour necrosis.

      



 

 

Speciality Spotlight

 

 

Melanoma
   

  • J Lee, Sanjay Logani, et al (N. W. Univ Med School, Chicago)
    Preretinal Neovascularisation Associated with Choroidal Melanoma
    BJO, Nov.2001, 85(11): 1309-1312
      
    The authors report 3 cases of choroidal melanoma with the very rare finding of overlying pre-retinal neovascularisation (NVE).
      
    All 3 patients had choroidal melanomas, localized serous retinal detachment and NVE.
      
    Two cases showed definite retinal capillary non-perfusion. One of these two patients showed retinal telangiectasis.
      
    One patient’s melanoma responded quickly to iodine-125 plaque radiotherapy but retinal neovascularization persisted and caused vitreous hemorrhage.
      
    Scatter photocoagulation was successful in causing the complete regression of neovascularization.
      
    The other 2 patients had their eyes enucleated, and in one of the cases preretinal vessels were seen in histological sections.
      
    Possible aetiologies of pre-retinal neovascularization include (i) release of tumor angiogenic factors (ii) inflammation (iii) chronic retinal detachment with secondary retinal ischemia (iv) retinal vascular occlusion secondary to retinal vessel invasion by the tumor or (v) following radiation therapy.
       

  • L Lumbroso, L Desjardins, et al (Opth.Dept. Institute Curie, Paris, France)    
    Intraocular inflammation after proton beam irradiation for uveal melanoma    
    BJO, 2001; 85:1305-1308   
                                                        
    Data from a cohort of patients with uveal melanoma who were treated by proton beam irradiation between 1991 and 1994 were analyzed.     
                         
    28% of patients treated during the above period presented with ocular inflammation.    
                                                 
    Risk factors were correlated with larger lesions. Multivariate analysis identified initial tumour height and irradiation of a large ocular volume as 2 important risk factors.           
                                              
    Ocular inflammation usually consisted of mild anterior uveitis, which resolved rapidly after use of local steroids and cycloplegics. 
                                           
    Inflammation may also be associated with tumour necrosis (spontaneous or after irradiation). Transient inflammation during follow-up of these patients maybe related to release of cytokines during tumour necrosis.
      

 

By |2022-07-20T16:43:52+00:00July 20, 2022|Uncategorized|Comments Off on Melanoma

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