Speciality
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Ophthalmology


 

 





Beta Blockers

     

  • L.M. Van Beck, M Mulder, N J van Haeringen, Aize Kijlstra. ( Dept of Ophthalmology, Leiden University, Netherlands; Dept of Allergy, CLB and Laboratory for Experimental and Clinical Immunology, Univ of Amsterdam, Netherlands).


    Topical ophthalmic b blockers may cause release of histamine through cytotoxic effects on inflammatory cells.



    Br. J Ophthalmol 2000; 84:1004-1007.


      


    A mixed leucyocyte and basophil preparation was obtained from venous blood of healthy non-atopic volunteers. Cell preparations were then incubated with betaxolol, metipranolol, timolol, or carteolol.

      


    One hour after incubation, the histamine content of the supernatant was analysed by automated fluorometric analysis. Cell viability was tested by measuring lactate dehydrogenase (LDH) concentrations.

      


    Betaxolol and metipranolol in concentrations between 10-2M and 10-3M liberated histamine from human blood cells in a dose dependent manner. Carteolol and timolol had NO effect on histamine at these concentrations.

      


    The authors conclude that betaxolol and metipranolol induce substantial histamine release from human leucocytes, probably as a result of their cytotoxic effect.

       


    This concurs with the observation that patients find timolol eye drops more comfortable than metripranolol or betaxolol eye drops.

      

 



 

 

Speciality Spotlight

 

 

Beta Blockers
     

  • L.M. Van Beck, M Mulder, N J van Haeringen, Aize Kijlstra. ( Dept of Ophthalmology, Leiden University, Netherlands; Dept of Allergy, CLB and Laboratory for Experimental and Clinical Immunology, Univ of Amsterdam, Netherlands).
    Topical ophthalmic b blockers may cause release of histamine through cytotoxic effects on inflammatory cells.
    Br. J Ophthalmol 2000; 84:1004-1007.
      
    A mixed leucyocyte and basophil preparation was obtained from venous blood of healthy non-atopic volunteers. Cell preparations were then incubated with betaxolol, metipranolol, timolol, or carteolol.
      
    One hour after incubation, the histamine content of the supernatant was analysed by automated fluorometric analysis. Cell viability was tested by measuring lactate dehydrogenase (LDH) concentrations.
      
    Betaxolol and metipranolol in concentrations between 10-2M and 10-3M liberated histamine from human blood cells in a dose dependent manner. Carteolol and timolol had NO effect on histamine at these concentrations.
      
    The authors conclude that betaxolol and metipranolol induce substantial histamine release from human leucocytes, probably as a result of their cytotoxic effect.
       
    This concurs with the observation that patients find timolol eye drops more comfortable than metripranolol or betaxolol eye drops.
      

 

 

By |2022-07-20T16:42:11+00:00July 20, 2022|Uncategorized|Comments Off on Beta Blockers

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