GOH Naumann, U Schlotzer-Scherhardt, M Kuchle (Univ of Erlangen-Nurnberg, Germany)
Pseudoexfoliation Syndrome for the Comprehensive Ophthalmologist:
Ophthalmology 105:951-968, 1998.
Pseudoexfoliation syndrome is both an ocular and a generalized disorder involving abnormal production and/or turnover of extracellular matrix material. All tissues of the anterior segment of the eye and extraocular tissues are involved. This syndrome should be suspected when the patient has circular or segmental posterior synechiae without any other obvious cause.
Slit-lamp examination, biocytology and laser-tyndallometry are used for clinical diagnosis.
The zonular apparatus, lens, iris, ciliary body, cornea and the trabecular meshwork are involved in this clinical entity. Complications reviewed include phacodonesis, lens dislocation, increased incidence of vitreous loss in extracapsular cataract extraction caused by alterations in the zonules. Open angle as well as angle-closure glaucoma may occur. Early diffuse corneal endothelial decompensation, anterior chamber hypoxia, iris stroma haemorrhage, poor or asymmetric mydriasis and posterior synechiae are the various clinical manifestations.