Speciality
Spotlight

 




 


Ophthalmology


 

 





Uveitis

   

  • Mulholland B, Marks M, Lightman S L, (Moorfields Eye Hospital, London, UK; Institute of Psychiatry, London; Institute of Ophthalmology, London).


    Anterior uveitis and its relation to stress



    Br.J.Opthalmology, 84(10); 1121-1124


      


    The authors observed that some patients with recurrent acute anterior uveitis (RAAU) related recurrences of inflammation to psychological factors.

      


    The study tested the hypothesis that stressful life effects may be associated with the onset of RAAU. It was found that stress is NOT involved in triggering the recurrence of idiopathic
    RAAU.

      

  • Kerkhoff FT, Rothova A, (Univ Hospital, Utrecht, Netherlands) 


    Bartonella henselae associated uveitis and HLA-B27



    Br.J Opthalmol 2000;84(10):1125-1129.


      


    Bartonella henselae, a Gram negative rod, was identified as the organism causing cat scratch disease (CSD). Ocular involvement in B.henselae infection has been reported to be the cause of
    Parinaud’s oculo-glandular syndrome, uveitis and neuroretinitis.

      


    The authors have investigated the frequency of HLA-B27 in presumed ocular bartonellosis and have reported the clinical features and laboratory data of these patients.

      

  • SR
    Rathinam, P Namperumalsamy, E.T. Cunningham Jr. (Aravind
    Eye Hosp. & PG Inst, of Ophthalmology, Madurai,
    Tamil Nadu, India & F.I. Proctor Foundation and
    the Dept. of Ophthalmology UCSF, Med Centre, San
    Francisco, CA, USA)

    Spontaneous cataract absorption in patients with
    leptospiral uveitis.

    BJO 2000; 84: 1135-1141.

      

    This article is a retrospective review of 394 eyes
    of 276 patients with seropositive leptospiral
    uveitis, seen in the uveitis clinic at Aravind Eye
    Hosp. Between January 1994 and December 1997.

      

    Of these, 54 eyes (13.7%) had a final visual acuity
    of 20/40 or worse attributable to cataract
    formation.

      

    Spontaneous cataract absorption was observed in 10
    eyes (18.5%) of 8 patients (19.5%) and occurred from
    6 weeks to 18 months, after the onset of cataract.

      

    Out of 12035 consecutive NON-leptospiral,
    non-traumatic, uveitic, control patients seen during
    the same 4 yrs of the study, NONE showed spontaneous
    cataract absorption.

      

    Spontaneous cataract absorption appears to be unique
    to this form of non-traumatic uveitis (occurring in
    patients with leptospirosis).                     

                                     

  • N Seider, I Beiran, J Scharf et al (Dept. of Ophth. Rambam Medical Center, Haifa, Israel)               

    Intravenous immunoglobulin therapy for resistant ocular Behcet’s disease.        

    BJO; 2001; 85:1287-88         

                    

    In this preliminary study, 6 eyes of 4 patients with ocular Behcet’s disease refractory to steroids and cyclosporin A were treated with a course of intravenous gammaglobulin and followed up for their response to this treatment.   

                        

    In all four patients and all 6 eyes there was good response to gammaglobulin therapy.                    

                                             

  • L Lumbroso, L Desjardins, et al (Opth.Dept. Institute Curie, Paris, France)    

    Intraocular inflammation after proton beam irradiation for uveal melanoma    

    BJO, 2001; 85:1305-1308   

                                                        

    Data from a cohort of patients with uveal melanoma who were treated by proton beam irradiation between 1991 and 1994 were analyzed.     

                         

    28% of patients treated during the above period presented with ocular inflammation.    

                                                 

    Risk factors were correlated with larger lesions. Multivariate analysis identified initial tumour height and irradiation of a large ocular volume as 2 important risk factors.           

                                              

    Ocular inflammation usually consisted of mild anterior uveitis, which resolved rapidly after use of local steroids and
    cycloplegics. 

                                           

    Inflammation may also be associated with tumour necrosis (spontaneous or after irradiation). Transient inflammation during follow-up of these patients maybe related to release of cytokines during tumour necrosis. 

 



 

 

Speciality Spotlight

 

 

Uveitis
   

  • Mulholland B, Marks M, Lightman S L, (Moorfields Eye Hospital, London, UK; Institute of Psychiatry, London; Institute of Ophthalmology, London).
    Anterior uveitis and its relation to stress
    Br.J.Opthalmology, 84(10); 1121-1124
      
    The authors observed that some patients with recurrent acute anterior uveitis (RAAU) related recurrences of inflammation to psychological factors.
      
    The study tested the hypothesis that stressful life effects may be associated with the onset of RAAU. It was found that stress is NOT involved in triggering the recurrence of idiopathic RAAU.
      

  • Kerkhoff FT, Rothova A, (Univ Hospital, Utrecht, Netherlands) 
    Bartonella henselae associated uveitis and HLA-B27
    Br.J Opthalmol 2000;84(10):1125-1129.
      
    Bartonella henselae, a Gram negative rod, was identified as the organism causing cat scratch disease (CSD). Ocular involvement in B.henselae infection has been reported to be the cause of Parinaud’s oculo-glandular syndrome, uveitis and neuroretinitis.
      
    The authors have investigated the frequency of HLA-B27 in presumed ocular bartonellosis and have reported the clinical features and laboratory data of these patients.
      

  • SR Rathinam, P Namperumalsamy, E.T. Cunningham Jr. (Aravind Eye Hosp. & PG Inst, of Ophthalmology, Madurai, Tamil Nadu, India & F.I. Proctor Foundation and the Dept. of Ophthalmology UCSF, Med Centre, San Francisco, CA, USA)
    Spontaneous cataract absorption in patients with leptospiral uveitis.
    BJO 2000; 84: 1135-1141.
      
    This article is a retrospective review of 394 eyes of 276 patients with seropositive leptospiral uveitis, seen in the uveitis clinic at Aravind Eye Hosp. Between January 1994 and December 1997.
      
    Of these, 54 eyes (13.7%) had a final visual acuity of 20/40 or worse attributable to cataract formation.
      
    Spontaneous cataract absorption was observed in 10 eyes (18.5%) of 8 patients (19.5%) and occurred from 6 weeks to 18 months, after the onset of cataract.
      
    Out of 12035 consecutive NON-leptospiral, non-traumatic, uveitic, control patients seen during the same 4 yrs of the study, NONE showed spontaneous cataract absorption.
      
    Spontaneous cataract absorption appears to be unique to this form of non-traumatic uveitis (occurring in patients with leptospirosis).                     
                                     

  • N Seider, I Beiran, J Scharf et al (Dept. of Ophth. Rambam Medical Center, Haifa, Israel)               
    Intravenous immunoglobulin therapy for resistant ocular Behcet’s disease.        
    BJO; 2001; 85:1287-88         
                    
    In this preliminary study, 6 eyes of 4 patients with ocular Behcet’s disease refractory to steroids and cyclosporin A were treated with a course of intravenous gammaglobulin and followed up for their response to this treatment.   
                        
    In all four patients and all 6 eyes there was good response to gammaglobulin therapy.                    
                                             

  • L Lumbroso, L Desjardins, et al (Opth.Dept. Institute Curie, Paris, France)    
    Intraocular inflammation after proton beam irradiation for uveal melanoma    
    BJO, 2001; 85:1305-1308   
                                                        
    Data from a cohort of patients with uveal melanoma who were treated by proton beam irradiation between 1991 and 1994 were analyzed.     
                         
    28% of patients treated during the above period presented with ocular inflammation.    
                                                 
    Risk factors were correlated with larger lesions. Multivariate analysis identified initial tumour height and irradiation of a large ocular volume as 2 important risk factors.           
                                              
    Ocular inflammation usually consisted of mild anterior uveitis, which resolved rapidly after use of local steroids and cycloplegics. 
                                           
    Inflammation may also be associated with tumour necrosis (spontaneous or after irradiation). Transient inflammation during follow-up of these patients maybe related to release of cytokines during tumour necrosis. 

 

 

By |2022-07-20T16:41:08+00:00July 20, 2022|Uncategorized|Comments Off on Uveitis

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