Mulholland B, Marks M, Lightman S L, (Moorfields Eye Hospital, London, UK; Institute of Psychiatry, London; Institute of Ophthalmology, London).
Anterior uveitis and its relation to stress
Br.J.Opthalmology, 84(10); 1121-1124
The authors observed that some patients with recurrent acute anterior uveitis (RAAU) related recurrences of inflammation to psychological factors.
The study tested the hypothesis that stressful life effects may be associated with the onset of RAAU. It was found that stress is NOT involved in triggering the recurrence of idiopathic RAAU.
Kerkhoff FT, Rothova A, (Univ Hospital, Utrecht, Netherlands)
Bartonella henselae associated uveitis and HLA-B27
Br.J Opthalmol 2000;84(10):1125-1129.
Bartonella henselae, a Gram negative rod, was identified as the organism causing cat scratch disease (CSD). Ocular involvement in B.henselae infection has been reported to be the cause of Parinaud’s oculo-glandular syndrome, uveitis and neuroretinitis.
The authors have investigated the frequency of HLA-B27 in presumed ocular bartonellosis and have reported the clinical features and laboratory data of these patients.
SR Rathinam, P Namperumalsamy, E.T. Cunningham Jr. (Aravind Eye Hosp. & PG Inst, of Ophthalmology, Madurai, Tamil Nadu, India & F.I. Proctor Foundation and the Dept. of Ophthalmology UCSF, Med Centre, San Francisco, CA, USA)
Spontaneous cataract absorption in patients with leptospiral uveitis.
BJO 2000; 84: 1135-1141.
This article is a retrospective review of 394 eyes of 276 patients with seropositive leptospiral uveitis, seen in the uveitis clinic at Aravind Eye Hosp. Between January 1994 and December 1997.
Of these, 54 eyes (13.7%) had a final visual acuity of 20/40 or worse attributable to cataract formation.
Spontaneous cataract absorption was observed in 10 eyes (18.5%) of 8 patients (19.5%) and occurred from 6 weeks to 18 months, after the onset of cataract.
Out of 12035 consecutive NON-leptospiral, non-traumatic, uveitic, control patients seen during the same 4 yrs of the study, NONE showed spontaneous cataract absorption.
Spontaneous cataract absorption appears to be unique to this form of non-traumatic uveitis (occurring in patients with leptospirosis).
N Seider, I Beiran, J Scharf et al (Dept. of Ophth. Rambam Medical Center, Haifa, Israel)
Intravenous immunoglobulin therapy for resistant ocular Behcets disease.
BJO; 2001; 85:1287-88
In this preliminary study, 6 eyes of 4 patients with ocular Behcets disease refractory to steroids and cyclosporin A were treated with a course of intravenous gammaglobulin and followed up for their response to this treatment.
In all four patients and all 6 eyes there was good response to gammaglobulin therapy.
L Lumbroso, L Desjardins, et al (Opth.Dept. Institute Curie, Paris, France)
Intraocular inflammation after proton beam irradiation for uveal melanoma
BJO, 2001; 85:1305-1308
Data from a cohort of patients with uveal melanoma who were treated by proton beam irradiation between 1991 and 1994 were analyzed.
28% of patients treated during the above period presented with ocular inflammation.
Risk factors were correlated with larger lesions. Multivariate analysis identified initial tumour height and irradiation of a large ocular volume as 2 important risk factors.
Ocular inflammation usually consisted of mild anterior uveitis, which resolved rapidly after use of local steroids and cycloplegics.
Inflammation may also be associated with tumour necrosis (spontaneous or after irradiation). Transient inflammation during follow-up of these patients maybe related to release of cytokines during tumour necrosis.