K Ohtsuka, M Hashimoto (Sapporo Med Univ, Japan)
1H-Magnetic Resonance Spectroscopy of Retrobulbar Tissue in Graves Ophthalmopathy.
Am J Ophthalmology 128: 715-719, 1999.

Proliferation of retrobulbar fibroblasts leading to Graves’ ophthalmopathy is accompanied by an accumulation of glycosaminoglycans. Glycosaminoglycans are molecules that absorb water. Retrobulbar tissue contains mainly chondroitin sulphate proteoglycans.

That accumulation of glycosaminoglycans plays a role in Graves disease was investigated by measuring their concentration in the orbits of patients, using 1H-magnetic resonance spectroscopy (MRS).

H-MRS can estimate the level of chondroitin sulphate protoglycan in retrobulbar tissue of patients with Graves’ ophthalmopathy. The findings did not correlate with the degree of exophthalmos.

K Ohtsuka, M Hashimoto (Sapporo Med Univ, Japan)1H-Magnetic Resonance Spectroscopy of Retrobulbar Tissue in Graves Ophthalmopathy.Am J Ophthalmology 128: 715-719, 1999.Proliferation of retrobulbar fibroblasts leading to Graves’ ophthalmopathy is accompanied by an accumulation of glycosaminoglycans. Glycosaminoglycans are molecules that absorb water. Retrobulbar tissue contains mainly chondroitin sulphate proteoglycans.That accumulation of glycosaminoglycans plays a role in Graves disease was investigated by measuring their concentration in the orbits of patients, using 1H-magnetic resonance spectroscopy (MRS).H-MRS can estimate the level of chondroitin sulphate protoglycan in retrobulbar tissue of patients with Graves’ ophthalmopathy. The findings did not correlate with the degree of exophthalmos.