& Test of
T, Ueda N, Ikeda
K, et al (Tohoko
Hearing Loss with a Mitochondrial Gene Mutation is Highly Prevalent in Japan.
Laryngoscope 109: 334 338, 1999
Sensorineural hearing loss (SNHL) of unclear origin may have a genetic basis in most patients. Mutations in the mitochondrial genome may make the individual sensitive to SNHL
In randomly selected patients with bilateral SNHL, 3% had nucleotide 3243 (nt3,243) mutation. This indicates that the SNHL caused by the nt3243 mutuation is widely distributed and may be one of the specific details of the genome