Otosclerosis

Otosclerosis
    

• Singhal SK, Mann SBS, Datta U, et al (Postgraduate Inst of Medical Education and Research, Chandigarh, India)
  Genetic Correlation in Otosclerosis
  Am J Otolaryngol 20: 102-105, 1999
     
  Otosclerosis is inherited in an autosomal-dominant manner and some authors have suggested association between this disease and ABO blood groups.
     
  100 patients of otosclerosis and 100 normal controls matched for age and sex underwent Human Leukocyte antigen (HLA) typing. The frequencies of the HLA antigens were then compared. Otosclerotic patients have significantly higher levels of HLA-A3, HLA-A9, HLA-A11 and HLA-B13 than controls. This suggested strongly HLA related component to the disease. Further HLA-A9 and HLA-A11 levels in patients with family history suggests genetic heterogenicity. Why HLA-A3 levels were significantly higher in females than males remain unknown.
     
  Otosclerotic, a genetic disease was always known. The authors and others are finding more specific ways in which genetic factors play a role. This is significant finding and such continued studies will shed more light.
        

• Grayeli AB, Palmer P, Tran Ba, Huy P, et al (Universite Paris; Hopital Lariboisiere, Paris; Hopital Pitie-Salpetriere, Paris; et al)
  No Evidence of Measles Virus in Stapes Samples from Patients with Otosclerosis 
  J Clin Microbiol 38: 2655-2660, 2000
        
  Previous reports of study of stapes samples suggested persistent infection with measles virus as a possible cause. In this study stapes samples from 35 patients of otosclerosis were studied.
       
  No evidence of persistent measles virus infection and no support to the previous reports. Available data suggests an unknown triggering agent acting on a complex genetic background. 
       
  Aactiologic basis as genetic has been thought.