- Stern Y, Heffelfinger SC, Walner DL, et al (Tel Aviv Univ, Israel; Univ of Cincinnati, Ohio)
Expression of Ki-67, Tumor Suppressor Proteins, Growth Factor, and Growth Factor Receptor in Juvenile Respiratory Papillomatosis: Ki-67 and p53 as Predictors of Aggressive Disease
Otolaryngol Head Neck Surg 122: 378-386, 2000
Human papillomavirus types 6 and 11 induces proliferation of epithelial cells to produce respiratory papillomas. The mechanism is unknown, how it is done. Overexpression of growth factor and inactivation of tumor suppressor proteins may be involved.
In 35 patients immunohistochemical study was carried out on surgically removed juvenile papillomas.
Patients with multiple disease sites and frequent recurrences had increased expression of Ki-67. Tumors undergoing malignant transformation had increased p53 expression.
According to R. A. Otto, Ki-67 is a nuclear antigen expressed in proliferative cells. P53 protein functions as a negative regulator of cell growth. When inactivated, loss of proliferation and cell growth control is caused. The high expression of p53 and its association with malignant transformation may be the result of p53 being bound, inactivated, and accumulated.