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Speciality Spotlight
Vestibulo
– Cochlea
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HH Wanamaker, L Gruenwald, KJ Damm, et al (Syracuse Univ, NY; Yamaguchi Univ, Japan).
Dose-related Vestibular and Cochlear Effects of Transtympanic Gentamicin.
Am J Otol 19:170-179, 1998.
A gerbil model used to test the relative cochlear and vestibular effects of transtympanically injected gentamicin, showed overall ototoxicity rather than selective vestibulotoxicity. Increase in the number of injections resulted in increased damage.
Gentamicin treatment to achieve vestibular ablation, also induces cochlear damage and associated hearing loss.