Speciality
Spotlight

 




 


Respiratory – Pulmonary – Asthma


 

 








critical care

     

  • VM
    Ranieri, PM Suter, C Tortorella, et al (Univ of
    Toronto)

    Effect
    of Mechanical Ventilation on Inflammatory Mediators
    in Patients with Acute Respiratory Distress
    Syndrome: A Randomized Controlled Trial.

    JAMA 282:54-61, 1999

       

    Mechanical
    ventilation can escalate or cause an inflammatory
    response and acute lung injury.
    The influence of mechanical ventilation on
    the lung and systemic cytokine release was assessed
    in patients with ARDS.

      

    Two
    groups were assessed (1) a control group and (2) a
    lung protective strategy group.

       

    At
    baseline physiologic characteristics and cytokine
    concentrations were similar.
    But after 24 and 36 hours, there were
    significant between-group differences in tidal
    volume, end-inspiratory plateau pressures and PEEP. The lung protective strategy group had significantly better
    results. It
    could be concluded that mechanical ventilation can
    produce a cytokine response that may be diminished
    by minimising overdistension and recruitment and
    derecruitment of the lung.

      
       


 



 

 

Speciality Spotlight

 

 

critical care
     

  • VM Ranieri, PM Suter, C Tortorella, et al (Univ of Toronto)
    Effect of Mechanical Ventilation on Inflammatory Mediators in Patients with Acute Respiratory Distress Syndrome: A Randomized Controlled Trial.
    JAMA 282:54-61, 1999
       
    Mechanical ventilation can escalate or cause an inflammatory response and acute lung injury. The influence of mechanical ventilation on the lung and systemic cytokine release was assessed in patients with ARDS.
      
    Two groups were assessed (1) a control group and (2) a lung protective strategy group.
       
    At baseline physiologic characteristics and cytokine concentrations were similar. But after 24 and 36 hours, there were significant between-group differences in tidal volume, end-inspiratory plateau pressures and PEEP. The lung protective strategy group had significantly better results. It could be concluded that mechanical ventilation can produce a cytokine response that may be diminished by minimising overdistension and recruitment and derecruitment of the lung.
      
       

 

 

By |2022-07-20T16:41:33+00:00July 20, 2022|Uncategorized|Comments Off on Respiratory – Pulmonary – Asthma

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