Speciality
Spotlight

 




 


Respiratory – Pulmonary – Asthma


 

 





Immunoglobulin

    

  • RA
    Erger, TB Casale, (Univ of Iowa, Iowa City; Nebraska Med Research Inst, Papillion)

    Interleukin-8 Plays a Significant Role in IgE-mediated Lung Inflammation.

    Eur Respir J 11:299-305, 1998

        

    In the article, IL-8 which is an important chemokine is thought to be more associated with neutrophil activation as opposed to eosinophil activation, is examined for its contribution to anti-IgE-treated induction of neutrophil and eosinophil migration, using lung samples taken from humans. The human lung IgE-mediated response in vitro has been shown to be dependent on IL-8 and IL-8 which is an important biological modifier in the induction and generation of granulocyte transcellular migration. 

       

    The recent findings that neutrophils may again resurrect a significant role in the inflammation in asthma, especially in the more potentially severe and fatal asthma, suggests that an understanding of its potential mechanism of induction of cellular accumulation and lung inflammation in asthma may be important, though indirect contributor to airway hyperresponsiveness. More importantly it may also be an indicator or marker of either fatal or severe asthma.

            

  • RD Tee, P Cullinan, J Welch, et al (Natl Heart and Lung Inst, London; Brimingham Chest Clinic, England)

    Specific IgE to Isocyanates: A Useful Diagnostic Role in Occupational Asthma

    J Allergy Clin Immunol 101: 709-715, 1998.

         

    Occupational asthma in the developed world is caused most frequently by isocyanates, which are used extensively in the manufacture of various articles of polyuretyhane polymers in foams, elastomers, adhesives, paints etc. Up to 10% of exposed workers develop occupational asthma. There are multiple specific inhalation tests in the laboratory, which may be considered to be the gold standard in the diagnosis of occupational asthma. However, the search continues for a faster, more cost-effective method. The authors have studied the usefulness of measuring specific immunoglobulin (IgE) antibody levels to isocyanates in the diagnosis of occupational asthma.

        

    The study included 58 patients diagnosed with isocyanate induced occupational asthma with serial peak flow records, history and traditional bronchial provocation tests. All patients had measurements taken by Phadebas radioallergosorben test (RAST) of specific IgE antibodies.

       

    A RAST ratio of 2 or greater to at least 1 type of isocyanate was taken to be significant.

       

    It was found that specific IgE to isocyanates is a more specific than sensitive index of occupational asthma and a 100% specific test is possible with a RAST score of 3 or greater, which would be diagnostic of isocyanate-induced asthma. This is especially true when the blood is collected in less than 30 days from last exposure in which case the sensitivity of specific IgE is highest. This is obviously in result with the consistency of the observed half-life. 

       

    Other antibody-based tests in occupational asthma, however have been less valuable in terms of sensitivity and specificity of diagnosis.

                 


 



 

 

Speciality Spotlight

 

 

Immunoglobulin
    

  • RA Erger, TB Casale, (Univ of Iowa, Iowa City; Nebraska Med Research Inst, Papillion)
    Interleukin-8 Plays a Significant Role in IgE-mediated Lung Inflammation.
    Eur Respir J 11:299-305, 1998
        
    In the article, IL-8 which is an important chemokine is thought to be more associated with neutrophil activation as opposed to eosinophil activation, is examined for its contribution to anti-IgE-treated induction of neutrophil and eosinophil migration, using lung samples taken from humans. The human lung IgE-mediated response in vitro has been shown to be dependent on IL-8 and IL-8 which is an important biological modifier in the induction and generation of granulocyte transcellular migration. 
       
    The recent findings that neutrophils may again resurrect a significant role in the inflammation in asthma, especially in the more potentially severe and fatal asthma, suggests that an understanding of its potential mechanism of induction of cellular accumulation and lung inflammation in asthma may be important, though indirect contributor to airway hyperresponsiveness. More importantly it may also be an indicator or marker of either fatal or severe asthma.
            

  • RD Tee, P Cullinan, J Welch, et al (Natl Heart and Lung Inst, London; Brimingham Chest Clinic, England)
    Specific IgE to Isocyanates: A Useful Diagnostic Role in Occupational Asthma
    J Allergy Clin Immunol 101: 709-715, 1998.
         
    Occupational asthma in the developed world is caused most frequently by isocyanates, which are used extensively in the manufacture of various articles of polyuretyhane polymers in foams, elastomers, adhesives, paints etc. Up to 10% of exposed workers develop occupational asthma. There are multiple specific inhalation tests in the laboratory, which may be considered to be the gold standard in the diagnosis of occupational asthma. However, the search continues for a faster, more cost-effective method. The authors have studied the usefulness of measuring specific immunoglobulin (IgE) antibody levels to isocyanates in the diagnosis of occupational asthma.
        
    The study included 58 patients diagnosed with isocyanate induced occupational asthma with serial peak flow records, history and traditional bronchial provocation tests. All patients had measurements taken by Phadebas radioallergosorben test (RAST) of specific IgE antibodies.
       
    A RAST ratio of 2 or greater to at least 1 type of isocyanate was taken to be significant.
       
    It was found that specific IgE to isocyanates is a more specific than sensitive index of occupational asthma and a 100% specific test is possible with a RAST score of 3 or greater, which would be diagnostic of isocyanate-induced asthma. This is especially true when the blood is collected in less than 30 days from last exposure in which case the sensitivity of specific IgE is highest. This is obviously in result with the consistency of the observed half-life. 
       
    Other antibody-based tests in occupational asthma, however have been less valuable in terms of sensitivity and specificity of diagnosis.
                 

 

 

By |2022-07-20T16:41:47+00:00July 20, 2022|Uncategorized|Comments Off on Immunoglobulin

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