TM Best, B Loitz-Ramage, DT Corr, et al (Univ of Wisconsin, Madison)
Hyperbaric Oxygen in the Treatment of Acute Muscle Stretch Injuries: Results in an Animal Model.
Am J Sports Med 26:367-372, 1998.
The effect of Hyperbaric Oxygen (HBO) therapy were studied in a rabbit model of acute muscle stretch injury.
Method : A standardised partial stretch injury of tibialis anterior muscle-tendon unit was created in 18 rabbits. The opposite limb was used as control starting 24 hours after the injury, one group of animals received HBO therapy (oxygen levels >95% at 2.5atm, 60 min/day for 5 days). The other group received no treatment. Tissue healing, functional and morphological indicators of recovery were assessed after 7 days.
Results: The functional deficit was significantly reduced in the HBO treated group. The percentage of ankle isometric torque on the injured side was 15% in the treated group versus 48% in the uninjured group. Surgical wound healing was quicker and on histology the HBO treated group showed reduced cellularity and fiber damage.
Conclusion: HBO therapy may help to hasten recovery after muscle stretch injury.
JM Beiner, P Jokl, J Cholewicki, et al (Yale Univ, New Haven, Conn)
The Effect of Anabolic Steroids and Corticosteroids on Healing of Muscle Contusion Injury.
Am J Sports Med 27: 2-9, 1999.
The effects of nandrolone, an anabolic steroid and methylprednisolone acetate (a corticosteroid) on muscle healing were studied in a rat model.
Methods: The muscle was injured using a drop-mass technique. Active contractile tension was measured in each muscle and histologic analysis was performed to determine healing.
Findings: With corticosteroids on day 2, there was significant improvement in the twitch and tetanic strength, but by day 7, this effect was reversed and on day 14, total degeneration was observed in the muscle. There was no significant effect in the anabolic steroid group.
Conclusion: Corticosteroids may be beneficial in the short term but results in irreversible damage in the long term. Anabolic steroids may facilitate healing of muscle contusion injury.