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Endoscopic
Surgery

         

  • Y. Fuuii, H. Tanaka and T. Kawasaki [ Departments of Anaesthesiology and ‘Surgery, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan]

    Randomized Clinical Trial of Granisetron, Droperidol and Metoclopramide for the Treatment of Nausea and Vomiting After Laparoscopic Cholecystectomy

    BRJ Volume 87, No.3, March 2000, Pg.Nos. 285-288

       

    Patients undergoing laparoscopic cholecystectomy [LC] may be especially at risk of experiencing postoperative nausea and vomiting [PONV].

      

    After experiencing PONV during the first 3 h after recovery from anaesthesia, 120 patients [78 women] received, in a randomized double-blind manner, granisetron 40mg/kg, droperidol 20mg/kg or metoclopramide 0.2mg/kg [n=40 per group] intravenously. Patients were then observed for 24 h after administration of the study drug.

      

    Complete control of established PONV, defined as no emetic symptoms and no need for another rescue antiemetic medication, was achieved in 88 per cent of patients with granisetron, 60 per cent with droperidol and 55 per cent with metoclopramide [p<0.05]. No clinically adverse events were observed in any of the groups.

      

    A high dose of granisetron [ 40mg/kg] was more effective than droperidol 20 mg/kg or metoclopramide 0.2 mg/kg for the treatment of established PONV after LC.

         

  



 

   

Speciality Spotlight

   

   
Surgery
   

 

Endoscopic Surgery
         

  • Y. Fuuii, H. Tanaka and T. Kawasaki [ Departments of Anaesthesiology and ‘Surgery, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan]
    Randomized Clinical Trial of Granisetron, Droperidol and Metoclopramide for the Treatment of Nausea and Vomiting After Laparoscopic Cholecystectomy
    BRJ Volume 87, No.3, March 2000, Pg.Nos. 285-288
       
    Patients undergoing laparoscopic cholecystectomy [LC] may be especially at risk of experiencing postoperative nausea and vomiting [PONV].
      
    After experiencing PONV during the first 3 h after recovery from anaesthesia, 120 patients [78 women] received, in a randomized double-blind manner, granisetron 40mg/kg, droperidol 20mg/kg or metoclopramide 0.2mg/kg [n=40 per group] intravenously. Patients were then observed for 24 h after administration of the study drug.
      
    Complete control of established PONV, defined as no emetic symptoms and no need for another rescue antiemetic medication, was achieved in 88 per cent of patients with granisetron, 60 per cent with droperidol and 55 per cent with metoclopramide [p<0.05]. No clinically adverse events were observed in any of the groups.
      
    A high dose of granisetron [ 40mg/kg] was more effective than droperidol 20 mg/kg or metoclopramide 0.2 mg/kg for the treatment of established PONV after LC.
         

  

 

By |2022-07-20T16:43:38+00:00July 20, 2022|Uncategorized|Comments Off on Endoscopic Surgery

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