Speciality
Spotlight

   




   

Surgery


   

 





Growth Factors and Wound Healing

     

  • Souba Willey W,MD ScD     

     
         

    Role of Growth Factors :

       

    (1)   Attracting macrophages to wound environment.

       

    (2)  
    Regulating synthesis of collagen and connective
    tissue.

        

    (3)   Angiogenesis.

        

    (4)   Tissue
    Remodelling.

         

    Explosion
    in biotechnology capabilities has allowed for the
    first time, the production of growth factors in large
    quantities. These
    compounds can be synthesized in megadoses by
    genetically engineered “smart bacteria”.

         

  • LN Jorgensen, F 
    Kallehave, E Christensen et al ,
    1998. (Univ of Copenhagen) : 

    Less
    Collagen Production in Smokers
    .  


    Surgery
    123: 450-455



         

    Smokers
    showed a specific impairment of subcutaneous collagen synthesis – consistent
    with reports of impaired wound healing in smokers.

        

    Patients
    should therefore be advised to quit smoking before
    undergoing surgery and even for ever after
    !!

  • J
    Lazarou, BH Pomeranz, PN Corey,
    1998.
    (Univ of 
    Toronto) :


    Incidence
    of Adverse Drug Reactions in Hospitalized Patients: A
    Meta-analysis of Prospective Studies
    . 
    JAMA 279:
    1200-1205

        

    There was a 6.7% overall incidence of serious adverse
    reactions, with a 0.32% incidence of fatal adverse
    reactions in hospitalized patients. 
    Serious adverse reactions in the USA estimated
    to number 2,216,000 in 1994 with fatal adverse
    reactions estimated to number 106,000 making adverse
    reactions between the 4th and 6th
    leading cause of death, ranking below heart disease,
    cancer, stroke, pulmonary disease and accidents and
    above pneumonia and diabetes.


       

  • MB
    Witte, FJ Thornton, T Kiyama et al 1998
    (Johns Hopkins Med Institutions, Baltimore, Md; Univ
    of Florida, Gainesville): Metalloproteinase
    inhibitors and wound healing: A Novel Enhancer of
    Wound Strength
    .  

    Surgery 124 : 464-470.

        

    Without an increase in collagen deposition .

        

    GM6001 – Novel inhibitor of metalloproteinase (MMPs) -
    its use decreased inflammatory infiltrate, the
    collagen content, and the collagen type I gene
    expression in the sponge granulomas.

  • M-L
    Ivarsson, M Bergstrom, E Eriksson et al ,
    1998.
    (Goteborg Univ, Sweden), 

    Tissue
    Markers As Predictors of Postoperative Adhesions.
       

    Br J
    Surg 85: 1549-1554

       

    Post-operative adhesions are associated with a
    decreased capacity to degrade intra-abdominally
    deposited fibrin, largely because of an increased
    expression of PAI-1 (Plasminogen activator inhibitor
    type1).

  • KE
    Rodgers, W Girgis, K St.Amand et al 

    Reduction
    of Adhesion Formation in Rabbits by Intraperitoneal 
    Administration of Lazaroid Formulations

    Hum
    Reprod 13 : 2443-2451

         

    Lazaroids exert their mechanism of action by
    inhibiting lipid peroxidation reactions as well as the
    production of reactive tissue metabolites. 
    Lazaroids could act to block the inhibition of
    fibrinolysis.



 

   

Speciality Spotlight

   

   
Surgery
   

 

Growth Factors and Wound Healing
     

  • Souba Willey W,MD ScD     
     
         
    Role of Growth Factors :
       
    (1)   Attracting macrophages to wound environment.
       
    (2)   Regulating synthesis of collagen and connective tissue.
        
    (3)   Angiogenesis.
        
    (4)   Tissue Remodelling.
         
    Explosion in biotechnology capabilities has allowed for the first time, the production of growth factors in large quantities. These compounds can be synthesized in megadoses by genetically engineered “smart bacteria”.
         

  • LN Jorgensen, F  Kallehave, E Christensen et al , 1998. (Univ of Copenhagen) : 
    Less Collagen Production in Smokers
    .  
    Surgery 123: 450-455

         
    Smokers showed a specific impairment of subcutaneous collagen synthesis – consistent with reports of impaired wound healing in smokers.
        
    Patients should therefore be advised to quit smoking before undergoing surgery and even for ever after !!

  • J Lazarou, BH Pomeranz, PN Corey, 1998. (Univ of  Toronto) :
    Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-analysis of Prospective Studies
    .  JAMA 279: 1200-1205
        
    There was a 6.7% overall incidence of serious adverse reactions, with a 0.32% incidence of fatal adverse reactions in hospitalized patients.  Serious adverse reactions in the USA estimated to number 2,216,000 in 1994 with fatal adverse reactions estimated to number 106,000 making adverse reactions between the 4th and 6th leading cause of death, ranking below heart disease, cancer, stroke, pulmonary disease and accidents and above pneumonia and diabetes.

       

  • MB Witte, FJ Thornton, T Kiyama et al 1998 (Johns Hopkins Med Institutions, Baltimore, Md; Univ of Florida, Gainesville): Metalloproteinase inhibitors and wound healing: A Novel Enhancer of Wound Strength.  
    Surgery 124 : 464-470.
        
    Without an increase in collagen deposition .
        
    GM6001 – Novel inhibitor of metalloproteinase (MMPs) - its use decreased inflammatory infiltrate, the collagen content, and the collagen type I gene expression in the sponge granulomas.

  • M-L Ivarsson, M Bergstrom, E Eriksson et al , 1998. (Goteborg Univ, Sweden), 
    Tissue Markers As Predictors of Postoperative Adhesions.   
    Br J Surg 85: 1549-1554
       
    Post-operative adhesions are associated with a decreased capacity to degrade intra-abdominally deposited fibrin, largely because of an increased expression of PAI-1 (Plasminogen activator inhibitor type1).

  • KE Rodgers, W Girgis, K St.Amand et al 
    Reduction of Adhesion Formation in Rabbits by Intraperitoneal  Administration of Lazaroid Formulations
    Hum Reprod 13 : 2443-2451
         
    Lazaroids exert their mechanism of action by inhibiting lipid peroxidation reactions as well as the production of reactive tissue metabolites.  Lazaroids could act to block the inhibition of fibrinolysis.

 

By |2022-07-20T16:43:37+00:00July 20, 2022|Uncategorized|Comments Off on Growth Factors And Wound Healing

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