MH Desai, R Mlcak, J Richardson et al,1998 (Univ of Texas, Galveston; Shriners Burns Inst, Galveston, Tex);
Reduction in Mortality in Pediatric Patients With Inhalation Injury with Aerosolized Heparin/N-acetylcysteine Therapy.
J Burn Care Rehabil 19:210-212,
Smoke inhalation injury is a major cause of death after burns.The injuries are associated with fibrin cast deposition in the airways as well as progressive carbon dioxide retention resulting from a ball valve effect.
Based on promising results on animal studies, a combination of aerosolized heparin and acetylcysteine was evaluated for the treatment of smoke inhalation injury in children.
The above regime reduced mortality, atelectasis and the need for reintubation. This mode of therapy addresses the pathophysiological mechanics of inhalation injury by reducing free radical ions and inhibiting fibrin cast formation.