Respiratory

Respiratory

  

• MH
  Desai, R Mlcak, J Richardson et al,1998 
  (Univ of Texas, Galveston; Shriners Burns Inst,
  Galveston, Tex);   
  
  Reduction
  in Mortality in Pediatric Patients With Inhalation
  Injury with Aerosolized Heparin/N-acetylcysteine
  Therapy.    
  
  J Burn
  Care Rehabil  19:210-212,
  
       
  
  Smoke
  inhalation injury is a major cause of death after
  burns.The injuries are associated with fibrin cast
  deposition in the airways as well as progressive
  carbon dioxide retention resulting from a ball valve
  effect.
  
       
  
  Based on promising results on animal studies, a
  combination of aerosolized heparin and acetylcysteine
  was evaluated for the treatment of smoke inhalation
  injury in children.
  
       
  
  The
  above regime reduced mortality, atelectasis and the
  need for reintubation.
  This mode of therapy addresses the
  pathophysiological mechanics of inhalation injury by
  reducing free radical ions and inhibiting fibrin cast
  formation.