Parsons CL, Greenberger M, Gabal L, et al [ Univ of California San Diego ]
The Role of Urinary Potassium in the Pathogenesis and Diagnosis of Interstitial Cystitis
J Urol 159 : 1862-1867, 1998
Background – Although anatomical epithelial abnormalities of the bladder are obvious, little is known about the functional disorders of the transitional cells in bladder lining.
Conclusions : – Chronic urinary potassium diffusion into the bladder interstitium may cause sensory symptoms, damage tissue, and may be an important factor in the pathogenesis of interstitial cystitis.
Intravesical potassium sensitivity reliably indicates abnormal epithelial permability, differentiating between patients with interstitial cystitis and normal subjects with intact epithelial function. It also useful diagnostic test for interstitial cystitis.
Sensitivity to potassium also occur in patients with urinary tract infection and occasionally in those with detrusor instability