Speciality
Spotlight

 




 

Urology

 

 







Testis Tumor 

  

  • TA Buchholz, TL Walden, BR Prestidge [ MD Anderson Cancer
    Ctr, Houston; Natl Cancer Inst, Bethesda, Md; Wilford Hall Med
    Ctr, Lackland AFB, Tex]


    Cost-Effectiveness of Posttreatment Surveillance After Radiation Therapy for Early Stage Seminoma


    Cancer 82: 1126-1133, 1998

        


    Conclusion – Nearly all patients with early-stage seminoma who undergo orchiectomy and postoperative lymph node irradiation have excellent disease-free and overall survival rates. Thus, the cost of surveillance, as carried out in this patient group, does not appear to be justified. An analysis of patterns of failure may lead to a more appropriate follow-up schedule. Singificant cost savings can be achieved by eliminating surveillance CT scans and limiting serum studies to selected patients.

         

  • Tognini PG, Foster RS, McGraw P, et al [Indiana Univ, Indianapolis]

    Combined Post-Chemotherapy retroperitoneal Lymph Node Dissection and Resection of Chest Tumor Under the Same anesthetic is Appropriate Based on
    Morbidity and Tumor Pathology

    J Urol 159: 1833-1835,1998

        


    One hundred forty three patients were reviewed retrospectively.

        



    Conclusion
    : The authors demonstrate that this approach is feasible and does not place the patient at undue risk for complications.

       


    Patients who are undergoing postchemotherapy retroperitoneal lymphadenectomy for uncomplicated indications do not need to undergo excision of the chest lesions if the retroperitoneal resection demonstrates necrosis.

        


    In that situation the residual chest abnormalities may be monitored.

        


    “Uncomplicated” are those patients who have normal tumor markers who have received the standard 1st line chemotherapy.
     

          

  • S. Baltaci, D. Orhan, K. Turkolmez, C. Yesilli, Y. Beduk and O. Tulunay (Departments of Urology and Pathology, University of Ankara School of Medicine, Ankara, Turkey)

    P53, bcl-2 and bax Immunoreactivity as Predictors of Response and Outcome after Chemotherapy for Metastatic Germ Cell Testicular Tumours

    BJU Intl. May 2001 Vol. 87 (7) Pg. 661-666

         


    Conclusion : The incidence of P53 and bax immunoreactivity in testicular GCTs is higher than that of bcl-2 immunoreactivity.

        


    However, only P53 immunoreactivity could be used to predict the response to chemotherapy. P53, bcl-2 and bax scores were not significant prognostic factors for survival after
    chemotherapy.

        




 

  

Speciality Spotlight

 

 
Urology
 

 

Testis Tumor 
  

  • TA Buchholz, TL Walden, BR Prestidge [ MD Anderson Cancer Ctr, Houston; Natl Cancer Inst, Bethesda, Md; Wilford Hall Med Ctr, Lackland AFB, Tex]
    Cost-Effectiveness of Posttreatment Surveillance After Radiation Therapy for Early Stage Seminoma
    Cancer 82: 1126-1133, 1998
        
    Conclusion – Nearly all patients with early-stage seminoma who undergo orchiectomy and postoperative lymph node irradiation have excellent disease-free and overall survival rates. Thus, the cost of surveillance, as carried out in this patient group, does not appear to be justified. An analysis of patterns of failure may lead to a more appropriate follow-up schedule. Singificant cost savings can be achieved by eliminating surveillance CT scans and limiting serum studies to selected patients.
         

  • Tognini PG, Foster RS, McGraw P, et al [Indiana Univ, Indianapolis]
    Combined Post-Chemotherapy retroperitoneal Lymph Node Dissection and Resection of Chest Tumor Under the Same anesthetic is Appropriate Based on Morbidity and Tumor Pathology
    J Urol 159: 1833-1835,1998
        
    One hundred forty three patients were reviewed retrospectively.
        
    Conclusion : The authors demonstrate that this approach is feasible and does not place the patient at undue risk for complications.
       
    Patients who are undergoing postchemotherapy retroperitoneal lymphadenectomy for uncomplicated indications do not need to undergo excision of the chest lesions if the retroperitoneal resection demonstrates necrosis.
        
    In that situation the residual chest abnormalities may be monitored.
        
    “Uncomplicated” are those patients who have normal tumor markers who have received the standard 1st line chemotherapy.  
          

  • S. Baltaci, D. Orhan, K. Turkolmez, C. Yesilli, Y. Beduk and O. Tulunay (Departments of Urology and Pathology, University of Ankara School of Medicine, Ankara, Turkey)
    P53, bcl-2 and bax Immunoreactivity as Predictors of Response and Outcome after Chemotherapy for Metastatic Germ Cell Testicular Tumours
    BJU Intl. May 2001 Vol. 87 (7) Pg. 661-666
         
    Conclusion : The incidence of P53 and bax immunoreactivity in testicular GCTs is higher than that of bcl-2 immunoreactivity.
        
    However, only P53 immunoreactivity could be used to predict the response to chemotherapy. P53, bcl-2 and bax scores were not significant prognostic factors for survival after chemotherapy.
        

 

By |2022-07-20T16:42:43+00:00July 20, 2022|Uncategorized|Comments Off on Testis Tumour

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