Speciality
Spotlight

 




 

Urology

 

 








Tumor Markers

 

Prostate Specific Antigen  

 

  • DG Bostwick, A Pacelli, M Blute et al [ Mayo Clinic and Mayo Found Rochester, Minn; Northwest Hosp, Seattle]

    Prostate Specific Membrane Antigen Expression in Prostatic Intraepithelial Neoplasia and Adenocarcinoma; A Study of 184 Cases

    Cancer 82:2256-2261, 1998

    Conclusion – Expression of specific membrane antigen [PSM] is clinically useful for identifying adenocarcinoma. Its expression is regulated independent of prostate specific antigen [PSA].

      


    Number of PSM immunoreactive cells did not predict recurrence, probably because of abundant immunoreactivity was present in most cases or because of differential expression in primary and metastatic disease.

       

  • DG
    Bostwick, A Pacelli, M Blute et al [ Mayo Clinic and Mayo Found Rochester,
    Minn; Northwest Hosp, Seattle]


    Prostate Specific Membrane Antigen Expression in Prostatic Intraepithelial Neoplasia and Adenocarcinoma; A Study of 184 Cases


    Cancer 82:2256-2261, 1998

       

    Conclusion – Expression of specific membrane antigen
    [PSM] is clinically useful for identifying
    adenocarcinoma. Its expression is regulated independent of prostate specific antigen
    [PSA].

         


    Number of PSM immunoreactive cells did not predict recurrence, probably because of abundant immunoreactivity was present in most cases or because of differential expression in primary and metastatic disease.

       

  • B
    Djavan, AR Zlotta G Byttebier, et al [ Univ hosp of Vienna; Univ Clinics of Brussels, Belgium]


    Prostate Specific Antigen Density of the Transition Zone for Early Detection of Prostate Cancer


    J Urol 160: 411-419, 1998

       


    Conclusion – Compared with other PSA parameters, Psa density of the transition zone increase the specificity of serum PSA for prostate cancer detection in patients with serum PSA ranging from 4 to 10
    ng/ml.

       


    Although PSA transition zone was more effective in prostate glands exceeding 30 cc and percent of free PSA was more effective in prostates of less than 30 cc, the combination of percent of free PSA and PSA transition zone further increases the prediction of prostate cancer.

 Tumour 

 

  • Tognini PG, Foster RS, McGraw P, et al [Indiana Univ, Indianapolis]

    Combined Post-Chemotherapy retroperitoneal Lymph Node Dissection and Resection of Chest Tumor Under the Same anesthetic is Appropriate Based on

    Morbidity and Tumor Pathology

    J Urol 159: 1833-1835,1998



    One hundred forty three patients were reviewed retrospectively.



    Conclusion – The authors demonstrate that this approach is feasible and does not place the patient at undue risk for complications.



    Patients who are undergoing postchemotherapy retroperitoneal lymphadenectomy for uncomplicated indications do not need to undergo excision of the chest lesions if the retroperitoneal resection demonstrates necrosis.



    In that situation the residual chest abnormalities may be monitored.



    “Uncomplicated” are those patients who have normal tumor markers who have received the standard 1st line chemotherapy.




 

  

Speciality Spotlight

 

 
Urology
 

 

Tumor Markers
 

Prostate Specific Antigen  
 

  • DG Bostwick, A Pacelli, M Blute et al [ Mayo Clinic and Mayo Found Rochester, Minn; Northwest Hosp, Seattle]
    Prostate Specific Membrane Antigen Expression in Prostatic Intraepithelial Neoplasia and Adenocarcinoma; A Study of 184 Cases
    Cancer 82:2256-2261, 1998
    Conclusion – Expression of specific membrane antigen [PSM] is clinically useful for identifying adenocarcinoma. Its expression is regulated independent of prostate specific antigen [PSA].
      
    Number of PSM immunoreactive cells did not predict recurrence, probably because of abundant immunoreactivity was present in most cases or because of differential expression in primary and metastatic disease.
       

  • DG Bostwick, A Pacelli, M Blute et al [ Mayo Clinic and Mayo Found Rochester, Minn; Northwest Hosp, Seattle]
    Prostate Specific Membrane Antigen Expression in Prostatic Intraepithelial Neoplasia and Adenocarcinoma; A Study of 184 Cases
    Cancer 82:2256-2261, 1998
       
    Conclusion – Expression of specific membrane antigen [PSM] is clinically useful for identifying adenocarcinoma. Its expression is regulated independent of prostate specific antigen [PSA].
         
    Number of PSM immunoreactive cells did not predict recurrence, probably because of abundant immunoreactivity was present in most cases or because of differential expression in primary and metastatic disease.
       

  • B Djavan, AR Zlotta G Byttebier, et al [ Univ hosp of Vienna; Univ Clinics of Brussels, Belgium]
    Prostate Specific Antigen Density of the Transition Zone for Early Detection of Prostate Cancer
    J Urol 160: 411-419, 1998
       
    Conclusion – Compared with other PSA parameters, Psa density of the transition zone increase the specificity of serum PSA for prostate cancer detection in patients with serum PSA ranging from 4 to 10 ng/ml.
       
    Although PSA transition zone was more effective in prostate glands exceeding 30 cc and percent of free PSA was more effective in prostates of less than 30 cc, the combination of percent of free PSA and PSA transition zone further increases the prediction of prostate cancer.

 Tumour 
 

  • Tognini PG, Foster RS, McGraw P, et al [Indiana Univ, Indianapolis]
    Combined Post-Chemotherapy retroperitoneal Lymph Node Dissection and Resection of Chest Tumor Under the Same anesthetic is Appropriate Based on
    Morbidity and Tumor Pathology
    J Urol 159: 1833-1835,1998

    One hundred forty three patients were reviewed retrospectively.

    Conclusion – The authors demonstrate that this approach is feasible and does not place the patient at undue risk for complications.

    Patients who are undergoing postchemotherapy retroperitoneal lymphadenectomy for uncomplicated indications do not need to undergo excision of the chest lesions if the retroperitoneal resection demonstrates necrosis.

    In that situation the residual chest abnormalities may be monitored.

    “Uncomplicated” are those patients who have normal tumor markers who have received the standard 1st line chemotherapy.

 

By |2022-07-20T16:42:39+00:00July 20, 2022|Uncategorized|Comments Off on Tumor Markers

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