K Hialmas, E Hanson, A-L Hellstrom , et al [Sahigrenska Univ Hosp/ East, Goteborg, Sweden]
Long-term Treatment with desmopressin in Children with Primary Monosymptomatic Nocturnal Enuresis An Open Multicentre Study
Br J Urol 82 : 704-709, 1998
Conclusions – One year of nasal desmopressin at doses of upto 40 mg/day was safe and effective in treating PMNE. Almost 2/3rd of these patients [61%] had 50% or greater decreases in their number of wet nights, and 18% of the patients became completely dry.
Initial studies of desmopressin did not evaluate long term efficacy and safety.
In this open study, 7% of patients had no response to DDAVP Only 18% were completely dry on medication which is a lower percentage than the 25% response reported in short term studies.
The number of patients “cured” with DDAVP did not exceed the annual spontaneous cure rate of 15%, but this is a safe, reasonably effective treatment of nocturnal enuresis.