Polycystic Kidney

Polycystic
Kidney

   

• Johnson
  AM, Gabsow PA [ Univ of Colorado , Denver; Denver
  Health]
  
  Identification of Patients with Autosomal
  Dominant Polycystic kidney Disease at Highest 
  
  J Am Soc Nephrol 8: 1560-1567, 1997
  
  
  
  Background – Renal cysts develop in virtually in all
  patients with a gene of autosomal dominant
  polycystic kidney disease. [ADPKD]
  
  
  
  However, factor other than the mulated ADKPD gene
  itself appear to influence progression to renal
  failure.
  
  
  
  Findings – Patients with ADPKD 2 gene had longer
  renal survival than those with the ADPKD 1
  gene. 
  
  
  
  Women had significantly better outcome than men. 
  
  
  
  Patients younger than 30 years when diagnosed and
  those with hypertension at an age of less than 35
  years had worse progress than those diagnosed after
  30 and 35 years respectively.
  
  
  
  Patients younger than 30 years who had an episode of
  gross hematuria also had a worse renal outcome than
  who did not.