- S. Mustonen, I.O. Ala-Houhala and T.L.J. Tammela [ Division of Urology and Department of Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland]
Characteristics of Protein Excretion in Patients With Acute Urinary Retention.
BJU International, volume 87, Number 1, January 2001, Pg.Nos. 187-191
Acute Urinary Retention causes disturbances in both the glomerular filtration and tubular reabsorption of proteins. Albuminuria and increased excretion of IgG, IgG4, and a1-microglobulin occurred in most patients during AUR. After relieving the retention, the albuminuria and elevated a1 -microglobulin level persisted indicating slight glomerular dysfunction and a permanent defect in the proximal tubule to reabsorb proteins. This could be caused partly by previous chronic obstruction.
AUR should be revealed immediately and the basic cause treated effectively to prevent further deterioration of renal function.
In this study; during AUR and after 1 and 6 months, albuminuria was detected in 100%, 92% and 54% of patients, and increased excretion of a-1 microglobulin in 52%, 36% and 58%, of IgG in 79%, 58% and 40% and of IgG4 in 67%, 42% and 20% respectively.
The mean GFR was normal during retention and during follow-up