Human Papillomavirus

human
papillomavirus

    

• Johnston
  C, Dept. of Obstetrics and Gynecology, University of
  Michigan Hospital, USA.
  
  Quantitative
  tests for human papillomavirus
  
  The
  Lancet, Vol.355, 24 June 2000
  
      
  
  Squamous-cell
  carcinoma of the cervix is thought to arise from
  squamous intraepithelial lesions (SIL). SILs are graded low or high in severity.
  These subdivisions reflect the relative
  potential of lesions for developing into invasive
  carcinoma. Research
  efforts to identify women at highest risk for the
  development of cervical cancer have focused on human
  papillomavirus (HPV) 16.
  
     
  
  Nathalie
  Ylitalo and colleagues found that not only does a
  high viral load of HPV 16 many years before the
  diagnosis of carcinoma in situ (CIS) increase the
  risk of developing CIS, but those women with
  persistently high loads have the highest risk.
  
      
  
  In
  the other study, Agnetha Josefsson and co-workers
  found that the average time between detection of HPV
  and development of CIS was 7-8 years.