Johnston C, Dept. of Obstetrics and Gynecology, University of Michigan Hospital, USA.
Quantitative tests for human papillomavirus
The Lancet, Vol.355, 24 June 2000
Squamous-cell carcinoma of the cervix is thought to arise from squamous intraepithelial lesions (SIL). SILs are graded low or high in severity. These subdivisions reflect the relative potential of lesions for developing into invasive carcinoma. Research efforts to identify women at highest risk for the development of cervical cancer have focused on human papillomavirus (HPV) 16.
Nathalie Ylitalo and colleagues found that not only does a high viral load of HPV 16 many years before the diagnosis of carcinoma in situ (CIS) increase the risk of developing CIS, but those women with persistently high loads have the highest risk.
In the other study, Agnetha Josefsson and co-workers found that the average time between detection of HPV and development of CIS was 7-8 years.